Possible Interaction: Arginine and Interleukin-10

“ Arginine treatment increased IL-10 and sIgA levels when compared with the Sham and IO groups (p < 0.05).”

“The leptin to ghrelin ratio was reduced in DBCB mice receiving R. Consumption of R increased IL-3 and IL-10 levels in both DBA/2J and DBCB mice.”

“ Arginine supplementation decreased (P< 0·05) the expression of IL-1β, Toll-like receptor 4 (TLR4) and PPAR-γ mRNA in the spleen and IL-1β, IL-10 , TLR4 and NF-κB mRNA in the caecal tonsils.”

“Stimulation with hyphal cells (S, R , and H) strongly increased IL-10 expression, but weakly reduced IL-1β expression.”

“Moreover, IL-10 levels were significantly increased in the wound fluid in hemorrhaged animals receiving L-arginine compared to vehicle-treated mice.”

“The challenge significantly increased serum procalcitonin levels, jejunal mucosal iNOS activities and jejunal IL-6, …, cationic amino acid transporter (CAT)-1, and CAT-3 mRNA expression (P < 0.05), whereas arginine supplementation significantly reduced jejunal …, IL-1β, IL-6, IL-10 , TGF-β3, and CAT-… expression (P < 0.05).”

“These results suggest that l-arginine modulates neonatal Tregs through the regulation of IL-10 promoter DNA methylation.”

“The results demonstrated that high doses of arginine increased IL-4, IL-10 and TNF-α secretion of T cells, while increasing concentrations of lysine increased IL-10 secretion and proliferative activity of the T cells.”