Possible Interaction: Arginine and Interferon Gamma-1B

“In contrast, NMA and arginase readily reversed the antimicrobial effect of mouse peritoneal macrophages stimulated either in vitro or in vivo by IFN-gamma , and activated mouse but not human cells could be induced to release enhanced levels of nitrite.”

“ Arginine with a concentration of 200 mM was sufficient to suppress aggregation of IFNβ-1b by decreasing the rate of pre-nucleation step.”

“ IFN-gamma inhibited the Fc epsilon R expression induced by PHA-sup, suggesting that the human counterpart of BSF-1 may be responsible for Fc epsilon R expression in bone marrow B cells.”

“…)%],IFN-gamma [(485.84 +/- 39.31) pg/ml], CD4+CD69+ T cells [(7.… +/- 0.87)%] and pDCs(CD11c+B220+) [(5.60 +/- 0.85)%] in L-Arg group was higher than those in control group [(36.46 +/- 1.33)%, (…/L, (10.02 +/- 0.37)%] and (9.01 +/- 0.53)%, respectively].”

“The elevated levels of Th(1) cytokines, namely TNF-alpha, IL-1beta, IFN-gamma , nitrite, and iNOS, decreased significantly both at +4 and +24 h of WBH, following L-arg administration.”

“Other medium components, such as insulin, arginine , aspartate and serine produced an inhibitory effect on both cell growth and IFN-gamma production.”

“ L-arginine treatment enhanced cytokine mRNA expression, particularly of IFN-gamma , which was detected earlier than in control animals, corresponding with the more rapid onset of disease and increased disease severity observed in this group.”

“ L-Arginine repletion also boosted NO production by macrophages cultured for up to 2 to 3 days in the presence of IFN-gamma plus LPS, but thereafter, iNOS was inactive in these cells whether or not L-arginine was repleted.”

“In L-arginine (1 mM)-containing medium, NO release from the M phi assessed by measuring NO2- increased as the concentration of IFN-gamma increased.”