Possible Interaction: Arginine and Insulin

“In conclusion, L-arginine increases the excretion of NOx and cGMP and increases plasma insulin , but the effect on sodium excretion depends upon salt intake.”

“ L-arginine increased plasma insulin concentration significantly (P < 0.05).”

“The amino acid, arginine , is known to stimulate insulin release and enhance glucose-stimulated insulin release.”

“Coinfusion of l-arginine with insulin caused a dose-dependent leftward shift of the vasodilator effect of l-arginine.”

“This stereospecific renal and ocular vasodilator potency of l-arginine is enhanced by insulin , which may result from facilitated l-arginine membrane transport, enhanced intracellular NO formation, or increased NO bioavailability.”

“We hypothesized that vasodilator effects of l-arginine may be dependent on insulin plasma levels.”

“OBJECTIVE To evaluate if insulin has a suppressive effect on the glucagon secretion stimulated by arginine in type 1 diabetes.”

“The lower percentage of increase of insulin release after arginine stimulation observed in the FK-506 and CsA groups as compared with controls (754%+/-100, 644%+/-102 vs. 1191%+/-174) (P<0.03 and 0.02, respectively), suggests a reduced beta cell secretory reserve in both treated groups.”

“Furthermore, l‐arginine improves insulin sensitivity in obese patients and NIDDM patients as well as in healthy subjects, indicating a possible mechanism that is different from the restoration of insulin‐mediated vasodilatation.”

“ Insulin sensitivity was improved significantly (P < 0.001) in all three groups by infusion of l‐arginine.”

“ Insulin levels with arginine infusion were significantly increased, and growth hormone levels decreased with bumetanide but not with furosemide.”

“We suggest that arginine stimulates insulin release by modulating the insulinogenic signal evoked by glucose in the β-cell, and not by its own primary action on the insulin-releasing machinery.”

“ Arginine infusion induced a brief 5 to 15 min increase in plasma concentrations of insulin that was not different in saline- and ACTH-treated foals.”

“Oral administration study in mice demonstrated that the stronger hypoglycemic effects were observed after coadministration of insulin with l-arginine.”

“The results demonstrated that a remarkable enhancement of intestinal insulin absorption was observed after coadministration of insulin with l-arginine.”