Possible Interaction: Arginine and Inosine Dialdehyde

“In conclusion, L-arginine increases the excretion of NOx and cGMP and increases plasma insulin, but the effect on sodium excretion depends upon salt intake.”

“Hence, co‐administration of Arg with HU may augment the NOx response in SCD and improve utilization of Arg in patients at steady state.”

“The combination of oral Arg and Cit (Arg + Cit) immediately and synergistically increases plasma Arg and nitrite/nitrate ( NOx ) concentrations more than either Cit or Arg alone.”

“After adjustment for all potential confounding variables, a significant positive association was observed between l-arginine intake and serum NOx concentrations in the fourth quartile of l-arginine (β = 6.63, 95% CI = 4.14, 9.12, p for trend = 0.001), an association stronger in women.”

“In three carriers receiving oral l-arginine , blood NOx concentrations were significantly higher.”

“ L-Arg supplementation enhanced iNOS and NOx expression in the cells.”

“l-NMMA reduced the output of NOx by 13–66% (95% confidence intervals) and secretion of fluid by 25–109% whereas l-arginine increased the output of NOx by 3–39% and secretion of fluid by 15–93%.”

“In the cirrhotic patients, urinary excretions of cyclic guanosine monophosphate (cGMP) and nitrates/nitrites NOx ) were significantly increased by L-arginine infusion, whereas no significant changes were seen with saline infusion.”

“Serum nitrate/nitrite NOx ) and interleukin (IL)-2 levels were significantly decreased by arginine in a dose-dependent manner.”

“ L-Arginine attenuated the RS-induced suppression of NOx levels in plasma and brain, whereas, the NO synthase inhibitors tended to produce reverse effects.”