Possible Interaction: Arginine and Indomethacin

“As predicted, urinary 6-keto-PGF1 alpha fell significantly after ingestion of indomethacin before the second infusion of arginine.”

“These changes in renal hemodynamics were blocked when the arginine or glucagon infusion was repeated after administration of indomethacin or ibuprofen.”

“In hypertensive patients, L-arginine and indomethacin had a synergistic positive effect on FMD.”

“Idiopathic menorrhagia arteries demonstrated enhanced basal tension after incubation with N(w)-nitro-L arginine methyl ester, which was further exaggerated by indomethacin.”

“Moreover, indomethacin restored the facilitatory effect of L-arginine (maximum flow increase: 804 +/- 56%; P < .01 versus indomethacin alone).”

“Despite lack of effect on plasma glucagon, indomethacin decreased the insulin response to arginine.”

“Both L-Arg and INDO had significant inhibitory effects on visceralization of leishmania in target organs.”

“Serum NO was inhibited by a combination therapy of L-Arg and INDO.”

“Pretreatment with L-arginine , a nitric oxide donor, protected against these effects of indomethacin.”

“… L-arginine (a NO synthase substrate) or sodium … 40% the antinociceptive effect of indomethacin (230.9+/-12.6 and 226.6+/-9.7 vs. 149.7+/-18.0 au, P<0.05), … no effect on the indomethacin antinociceptive response (208.0+/-34.9 vs. 149.7+/-18.0 au).”

“Pretreatment of animals with allopurinol, arginine or zinc protected against these effects of indomethacin.”

“Neurogenic relaxation of the prostatic tissue was improved by combined treatment with indomethacin and L-arginine in the hypercholesterolemia but not in the chronic prostate ischemia group.”