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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Imidazole binding was strictly competitive with L-arginine , indicating a domain overlap.”
“ Imidazole (2.2 mM) also perturbed the Kd of L-arginine from 3.03 +/- 0.45 to 209 +/- 10 microM. The observed increase in the Kd for L-arginine is consistent with imidazole being a competitive inhibitor versus L-arginine.”
Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.“ Imidazole induced a type II difference spectrum, reversible by L-Arg.”
“In the present study we describe competition between arginine and imidazole at the axial heme ligand position; a second imidazole, which occupies part of the arginine site in some crystal structures, is too weak to contribute to the equilibria.”
Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding.“Enzyme kinetic experiments showed that imidazole enhanced the apparent K m for l‐arginine without affecting maximal enzyme activity, and binding studies revealed that the inhibitor displaced the radioligand N G‐nitro‐l‐[3H]arginine in a concentration‐dependent fashion.”
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