Possible Interaction: Arginine and Ibuprofen

“By combining ibuprofen with L-arginine , the potential exists for delivering ibuprofen in a faster, more effective formulation that would presumably result in a faster onset of action.”

“These changes in renal hemodynamics were blocked when the arginine or glucagon infusion was repeated after administration of indomethacin or ibuprofen.”

“ Arginine has high probability of being the "best" in the pool followed by ibuprofen.”

“On the other hand, l-arginine administered at a dose of 6 g/l in drinking water together with ibuprofen or fluoxetine reversed their effect on FST, TST and cerebral PGE2 and NO levels.”

“In conclusion, the coupling of L-Arg to Ibuprofen is an attractive alternative to Ibuprofen administration alone because it not only attenuates but also improves the evolution of chronic lesions through mechanisms that implicate endogenous PG and FGF-2-associated pathways, which allow an increase of angiogenesis process.”

“In contrast, treatment with L-Arg reduced the delay of the lesion, the increment in COX-2 expression induced by Ibuprofen , and was able to maintain PGE2 levels similar to the control group after 14 days.”

“The protective effect of oral l-arg (100 mg/kg body wt), administerred together with IBP (100 mg/kg body wt, per os), was evident enough 90 min after drug administration, although a significant protection persisted for more than 6 hr.”

“The antinociceptive effects of diclofenac, ibuprofen and paracetamol were reversed by L-arginine , but not by D-arginine.”

“The enzymes associated with co-metabolism of l-arginine , l-phenyloalanine and putrescine may be linked to ibuprofen transformations.”