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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Hydroxyurea
Research Papers that Mention the Interaction
“Conclusions: While Arg alone does not increase serum NOx production in SCD patients at steady state, it does when given together with HU.”
“Hence, co‐administration of Arg with HU may augment the NOx response in SCD and improve utilization of Arg in patients at steady state.”
Hydroxyurea and Arginine Therapy: Impact on Nitric Oxide Production in Sickle Cell Disease“Furthermore, arginine at concentrations >100μM in combination with varying concentrations of HU , decreased HbF synthesis compared to HU controls.”
“NOx] in the HbAA and HbSS cultures treated with a clinically relevant dose of HU (1.0 mM) plus 1.0 mM L-arginine was significantly greater than that in controls incubated with PBS and with L-arginine p < 0.01.”
“We found that HU significantly increases the release of arginine vasopressin but not that of corticotrophin-releasing hormone in short-term incubation experiments.”
Hydroxyurea induces vasopressin release and cytokine gene expression in the rat hypothalamus“In adults co-administration of hydroxyurea and L-Arginine in adult sufferers of SCD had shown some benefits.”
Blood pressure, hematologic and biochemical changes following L-arginine supplementation in children with sickle cell anaemia already on hydroxyurea therapy.“ Hydroxyurea inhibits incorporation of [3H]arginine in callus tissues, whereas in tumorous tissues, apart from inhibition (at 75 and 100 mg HU/1), the stimulation of incorporation of this amino acid was observed (at 10 and 50 mg HU/1).”
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