Possible Interaction: Arginine and Hydroxyproline

“Studies of acutely wounded young animals, as well as studies of skin wound strength in elderly humans, have concluded that arginine supplementation improves not only general nutritional status but also hydroxyproline content and wound tensile strength.”

“The overall meta-analysis demonstrated a significant effect of arginine supplementation on hydroxyproline content (MD: 4.49, 95% CI: 3.54, 4.45, p < 0.00001).”

“Furthermore, L-arg significantly inhibited the production of procollagen III and total collagen in the supernatants determined by radioimmunoassay and hydroxyproline colorimetric assay (P < 0.05 and 0.01, respectively) and inhibited the expression of collagen IV mRNA determined by RT-PCR (P < 0.01).”

“Muscle protein, lipid and nitric oxide contents, shear force, hydroxyproline concentration, and pH were significantly improved by appropriate arginine.”

“ L‐arginine significantly enhanced wound breaking strengths in both control (+23%) and diabetic animals (+44%), and also increased wound hydroxyproline levels in both diabetic (+40%) and control animals (+24%) as compared to their saline‐treated counterparts.”

“In addition, ARG decreased the extent of BLM-induced elevations of lung HP and LP levels.”

“When L-arginine was administered in L-NAME pretreated rats, it significantly elevated wound HP content.”

“ Arginine also increased hydroxyproline deposition in a specific wound area (5.5 vs. 4.1 mg in one experiment and 3.1 vs. 1.9 mg.”