Possible Interaction: Arginine and Hydrogen Peroxide

“The superior bleaching effects exhibited by R HAp-TiO2 with H2O2 suggest that this combination may lead to novel methods for the clinical application of bleaching treatments.”

“ Arginine also led to significant increases in α-ketoglutarate, pyruvate, MPO release and H2O2 generation.”

“These results suggest that arginine prevents the undesirable attack by hydrogen peroxide on hair proteins and hair surface lipids.”

“In the second part, low H2O2 (180μM) showed alanine, aspartate and glutamate metabolism, but high H2O2 (1800μM) also up-regulated arginine and proline metabolism, as in the control group without H2O2 stimulus.”

“ Liver hydroperoxide and thiobarbituric-acid-reactive substance (TBARS) levels were decreased by Arg and increased by l-NAME or DIS treatments.”

“T. cruzi epimastigotes treated with hydrogen peroxide presented a time-dependent increase in arginine kinase expression, up to 10-fold, when compared with untreated parasites.”

“ H2O2 produced a concentration-dependent reduction of cell viability, which was blocked by (5 R,10 S)-(+)-5-methyl-10,11-dihydro-5 … (MK-801), an N-methyl- D-aspartate (NMDA) receptor antagonist, verapamil, an L-type Ca 2+ channel blocker, and NG-nitro- L-arginine methyl ester (L-….”

“We found H2O2 assisted product formation from N‐hydroxy‐L‐arginine and even from L‐arginine both in the presence and in absence of tetrahydrobiopterin.”

“Treatment with H2O2 (125-1000 microM) concentration dependently increased L-Cit formation from L-Arg , and a peak was obtained at 90 min after the addition of 500 or 1000 microM H2O2.”

“These findings suggest that the maximum L-citrulline formation from L-arginine , coupled with NOS activity, was increased by H2O2 treatment before cell death.”