Possible Interaction: Arginine and Hydrocortisone

“The increase in the … weeks of use of HC + L-arginine , in relation to the baseline, demonstrates that such association induces a better therapeutic response to HC and confirms that … pathway causing increased consumption of L-arginine, which is reduced in SCA patients and limits their response to HC.”

“ Cortisol was significantly higher in R than E at three points during operation.”

“On the other hand, in the presence of hydrocortisone, plasma arginine vasopressin fell in response to a decrease in plasma osmolality and plasma atrial natriuretic hormone increased, thereby restoring urinary dilution and excretion.”

“Mean 24-h urinary cortisol levels were significantly elevated (P less than 0.001) in six AR [45.1 +/- 7.2 (+/- SEM) micrograms/24 h] and eight R (38.5 +/- 6.9 micrograms/24 h) compared to four NC (13.9 +/- 2.8 micrograms/24 h).”

“Results The L-arginine 1 μg/rat decreased the level of cortisol , water and food intake and time of feeding and increased the adrenal weight.”

“Enhancement of NO with L-arginine resulted in a significant reduction of ACTH-mediated cortisol production in the LTH group.”

“Furthermore, 0.5 or 1% arginine decreased the cortisol receptor mRNA level in muscle (P < 0.05).”

“Supplementing 0.5 or 1% arginine to the diet increased arginine concentration and decreased cortisol level in serum, while enhancing antioxidative capacity and glutathione peroxidase activity in serum (P < 0.05).”

“ Cortisol (5-50mug/ml) or glucagon (0.067-67mug/ml) also increased the arginine synthetase system activity above the respective control values, but there was no increase in activity with insulin (0.05-0.25i.u./ml).”