supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Arginine
supplement:
Homocysteine
Research Papers that Mention the Interaction
“The change in plasma L-arginine was inversely correlated with the change in plasma homocysteine (r = -0.57, P = 0.03).”
Oral L-arginine improves hemodynamic responses to stress and reduces plasma homocysteine in hypercholesterolemic men.“ Arginine and taurine may protect against cardiovascular diseases while homocysteine may be a risk factor for them.”
“In conclusion, HCy is negatively associated with A2A R production in CAD patients, as well as with A2A R and cAMP production in cellulo.”
“We observed a negative correlation between HCy concentration and A2A R production (r = −0.43; P < 0.0001), with decreased A2A R production above 25 µM HCy.”
“Inhibition by l–Hcy and dl–Hcy of system y+L activity was Na+ sensitive with a significant inhibition constant (Ki) shift observed following K+ replacement; l arginine reduced [35S]l– Hcy uptake by ∼19%.”
“ Homocysteine also dose-dependently inhibited insulinotropic responses to a range of glucose-dependent secretagogues including nutrients (alanine, arginine , 2-ketoisocaproate), hormones (glucagon-like peptide-1 (7-36)amide, gastric inhibitory polypeptide and cholecystokinin-8), neurotransmitter (carbachol), drug (tolbutamide) as well as a depolarising concentration of KCl or elevated Ca2+.”
“Moreover, Hcy and TNF-α levels were reduced in L-Arg supplemented group.”
L-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats.“ HCY induced formation of the peroxynitrite biomarker nitrotyrosine, which was blocked by supplemental L-arginine.”
“ HCY treatment for 6 hr increased L-arginine uptake by 34%; however, uptake was decreased by 25% after 24 h. HCY caused membrane hyperpolarization during both 6 and 24 h incubation periods, indicating that the negative charge facilitating arginine uptake was maintained.”
“In endothelial cells, HCY had a biphasic effect on arginine transport.”
“Insulinotropic responses to alanine, arginine , 2-ketoisocaproate, elevated Ca2+, tolbutamide, potassium chloride (KCl), forskolin, and phorbol 12-myristate 13-acetate were also significantly reduced by homocysteine.”
“ Arginine supplementation reduced the weight of abdominal (retroperitoneal) and epididymal adipose tissues (45 and 25%, respectively) as well as serum concentrations of glucose (25%), triglycerides (23%), FFA (27%), homocysteine (26%), dimethylarginines (18-21%), and leptin (32%).”
“The co‐incubation of Hcy with L‐arginine ameliorated the Hcy‐mediated collagen gel constriction.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback