Possible Interaction: Arginine and Guanidines

“The inhibitory nature of guanidine and arginine toward the esterase activity is reported.”

“Both the guanidino side chain and the free carboxyl of the arginine participate in the interaction.”

“Interestingly, N-acetylated arginine, which lacks the α-amino group, showed a weaker suppressive effect on protein aggregation than Arg, even at neutral pH. These results indicate that both positively charged α-amino group and guanidinium group play important roles in suppressing heat-induced protein aggregation by Arg.”

“The concentration of L-arginine (0.05 nmol/mg tissue) is significantly lower than the other guanidines.”

“Exposure of arginine kinase to 6 M guanidinium chloride results in a shift to shorter lifetimes and narrowing of the lifetime distributions.”

“A similar inhibition of macrophage leishmanicidal activity and of NO2 ‐ release was observed using media treated with arginase (which converts L‐arg to urea and ornithine), or supplemented with NG‐monomethyl‐L‐arg or guanidine (which inhibit the conversion of L‐arg to nitrogen oxidation products).”

“ Arginine was extremely correlated with guanidines.”

“ Arginine , an essential amino acid found in many interaction interfaces, is capable of an impressive range of interactions via its guanidinium group.”

“Recent experiments suggest that the dissociation constant for arginine is much higher than 12.5, which explains why the arginine guanidinium group retains its positive charge under all physiological conditions.”

“The …, arginine … guanidine/guanidinium side chain at close range above the open coordination site lying between the Ni and Fe atoms (N-metal distance of 4.4 Å): … lysine lowers the H2 oxidation rate by nearly 2 orders of magnitude and markedly decreases the H2/D2 kinetic isotope effect.”