supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Arginine
Research Papers that Mention the Interaction
“Our data demonstrate that, in contrast to … had little effect on ghrelin, combined GHRH … arginine significantly stimulated ghrelin with a maximal peak at 120 min, representing a change of 66 +/- 14 pg/….001 by repeated-measures ANOVA and P = 0.02 for GHRH vs. combined GHRH-arginine by MANOVA).”
Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men.“ GHRH … ARG significantly stimulated the secretions of 22 kDa- and 20 kDa-GH in nonobese (at 30, 45, 60 and 90 min and at 45, 60, … 0 min, p<0.05, with GH peaks of 12.5±9.0 ng/ml and 2.0±1.8 ng/ml, respectively).”
“On admission, basal GH was 0.10 ng/ml and peak GH was 0.21 ng/ml after GH-releasing hormone plus arginine , which met the criteria for GHD.”
“Testing with GH releasing hormone (GHRH) alone has no diagnostic value, but when GHRH is given in combination with arginine or pyridostigmine it becomes the most potent and reproducible provocative test to evaluate the maximal secretory capacity of somatotrope cells.”
“However, the second combined administration of arginine and GHRH induced a GH increase which was lower compared to the first one (p = 0.016).”
“When every GHRH bolus was combined with arginine a marked potentiation of GH response to both boluses was found.”
“Coadministration of GHRH accentuated the stimulatory effect of arginine on GH secretion.”
“ ARG treatment decreased GnRH secretion after 24h (P<0.05), whereas it had no effect after 12h.”
“High concentrations of NCG (1.0mM) and ARG (4.0mM) inhibited (P<0.05) GnRH and nNOS mRNA abundance in GT1-7 cells.”
“Thus, high concentrations of NCG (1.0mM) and ARG (4.0mM) may act both directly and indirectly to regulate GnRH neuron function by downregulating genes related to GnRH synthesis and secretion to slow GnRH production while stimulating GT1-7 cell proliferation.”
Effects of N-carbamylglutamate and L-arginine on gonadotrophin-releasing hormone (GnRH) gene expression and secretion in GT1-7 cells.“Using patch-clamp recordings from GnRH neurons expressing green fluorescent protein in adult mice brain slices, we demonstrate that the NO precursor, L-arginine (Arg), or the NO donor, diethylamine/NO, induced a robust and reversible reduction in the spontaneous firing activity of GnRH neurons, including bursting activity.”
“Although 10 mM of L-Arg significantly stimulated GnRH and c-GMP, but not neuropeptide Y, levels in both the MPOA and ME-ARC, GnRH and c-GMP in the ME-ARC were already increased by 1.0 mM of L-Arg.”
“ L-Arginine (10(-2) M), a precursor of NO enhances basal GnRH secretion.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback