Possible Interaction: Arginine and Glycine

“Furthermore, interspersing arginines with glycine and histidine residues achieved reversible plasmid condensation and dramatically increased transfection levels in a variety of cell types.”

“Infusion of arginine 30 min after the completion of glycine infusion was associated with a reduction of blood glycine levels, but not more than that accountable by the effect of time.”

“Treatment with L-Arginine significantly reduced both the proband’s glycine and ammonia levels, in turn aiding in control of seizures and mental status.”

“The amino acid substitution of a glycine to arginine resulted in a markedly reduced steady-state level of the IVD protein, which explains the nearly complete lack of IVD enzyme activity as assessed in fibroblast homogenates.”

“Furthermore, glycine significantly elevates arginine serum levels.”

“ObjectiveIt has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function.”

“BACKGROUND It has been argued that arginine replacement in locus 16 (Arg16) of beta 2 adrenergic receptor with glycin (Gly16) increases asthma severity, while glutamin replacement in locus 27 (Gln27) with glutamic acid (Glu27) decreases it.”

“Furthermore, the conserved arginine in the G1 box plays a role in the activity of ScRheb, as a mutation of this arginine to glycine significantly reduced the ability of ScRheb to complement canavanine hypersensitivity of ScRheb-deficient yeast.”

“Single crystals have also been grown of a …-specific mutant for which the replacement of an arginine (Arg-… glycine has been shown to not only drastically affect the enzyme activity but also its kinetic …, L. C., Miller, A. W., Lee, S., and Kozuma, C. (1988) Biochemistry 27, 8823-8832).”

“ l-Arginine injected intravenously during the glycine infusion produced an abrupt cessation of ammonia release by the liver and caused this organ to remove ammonia from the incoming blood.”