Possible Interaction: Arginine and Glyburide

“Gliclazide, but not glibenclamide , significantly reduced the systolic and diastolic blood pressure (P=.0199 and P=.00199, respectively, two-way repeated-measures analysis of variance) in response to intravenous L-arginine.”

“The results showed that the NOS substrate (L-Arg), PKA donor (8-Br-cAMP) decreased the reactivity of shock 0.5 h-lymphatics, and that the PKA inhibitor (H-89) and KATP inhibitor glibenclamide ) restrained the effects of L-Arg while glibenclamide abolished the effects of 8-Br-cAMP.”

“There is a trend for N-nitro L-arginine methyl-ester hydrochloride to increase all parameters of arrhythmias in SCH79797 dihydrochloride (25 µg/kg) treated rats, but glibenclamide (5 mg/kg) significantly (p < 0.05) increased these parameters.”

“Pretreatment with ODQ or glibenclamide reversed the protective effects of SNP and L-Arg.”

“K(ATP) channel blocker, glibenclamide (3 microM), abolished the vasorelaxant responses of L-arginine in endothelium-denuded preparations, thereby suggesting the involvement of KATP channels.”

“Blockade of … by glibenclamide prior to insulin … length at R (–58 ± 6% of baseline with higher concentration), attenuated leakage at R (0.30 ± 0.04 NGL, according to higher concentration) … adhesion mainly in V1 venules at R (9.0 ± 1.5/100 µm of venular length, with higher concentration).”

“In the presence of glybenclamide , the effects of arginine became antiabsorptive, as had those observed in preceding studies with high arginine concentration.”

“Injection of glybenclamide sharply decreased all absorption markers in arginine supplemented oral rehydration solution, which were at least partially restored by addition of gum arabic to the oral rehydration solution.”

“Culture with 100 microM glibenclamide also markedly reduced the acute insulinotropic actions of glucose, L-alanine, L-arginine , 2-ketoisocaproic acid (KIC) and KCl.”

“ L-Arg reduced IS compared with control (24 +/- 2% vs 49 +/- 3%, P < 0.05); this was reversed …-NAME (53 +/- 4%, P < 0.05) or MB (43 +/- 3%, P < 0.05), but not by glibenclamide (20 +/- 4%), unlike the increase in CF …-Arg infusion, which was blocked by glibenclamide.”

“infusion of glibenclamide (0.16 mg/kg per min) reversed net fluid absorption to net secretion, blocked the absorptive effect of L-arginine (8.88 mg/kg per min) and reduced the proabsorptive effect of cromakalim.”