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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Mutation of these highly conserved arginines , including a replication of the prevalent MMACHC missense mutation, Arg161Gln, disrupts GSH binding and dealkylation.”
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.“More importantly, the probe revealed that NO induced by interferon-γ (IFN-γ), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH.”
BODIPY-Based Fluorescent Probe for Dual-Channel Detection of Nitric Oxide and Glutathione: Visualization of Cross-Talk in Living Cells.“The present study demonstrates that the supplementation of l-arginine stimulates GSH synthesis and activates Nrf2 pathway, leading to the up-regulation of ARE-driven antioxidant expressions via Nrf2-Keap1 pathway.”
“ L-arginine significantly decreased serum creatinine, BUN and GSH (p ≤ 0.05) and caused significant elevation in liver enzymes and NO (p ≤ 0.05), and also in MDA levels (p ≤ 0.001) in liver tissues.”
“ L-arginine increased total cellular GSH and glutamate levels but reduced the GSSG/GSH ratio and glutamate release.”
“ R and M completely prevented PH-induced lipid peroxidation, decreased hepatic GSH and NO levels (P < .05).”
“The tissue GSH levels were slightly decreased in PH + R (P < .05), and decreased in the PH group compared with the controls (P = .002).”
“ L-Arg administration also significantly increased the GSH levels in plasma.”
“On the other hand, L-arginine significantly decreased pulmonary artery pressure and both tissue and perfusate glutathione levels, but it increased both tissue and perfusate MDA levels.”
“In addition, L-arg prevented the rise of MDA as well as reduction of GSH-Px activity and reduced GSH content in kidney tissue.”
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