Possible Interaction: Arginine and Glucagon

“ L-arginine given intravenously at a dose of 300 mg/kg/h significantly increased plasma glucagon and somatostatin in fasted patients and increased postprandially released glucagon without affecting postprandial plasma somatostatin levels.”

“We investigated whether glucagon may mediate the increase in RPF and GFR induced by an arginine infusion and whether prostaglandins are required for this effect.”

“At baseline glucose, L-arginine increased total and active GLP-1 and glucagon concentrations in all GT populations (all P < 0.05).”

“We hypothesized that consumption of a specific combination of amino acids arginine , alanine, and phenylalanine; A-mix) may be involved in secretion of glucagon , and when combined with exercise may promote fat catabolism.”

“Plasma glucagon showed an exaggerated response to L-arginine before treatment.”

“The chronic exposure to glucagon also reduced the glucagon response to arginine (- 4.9 +/- 5.7 vs 19.9 +/- 7.9 pg/islet per 20 min, P < 0.05) without affecting the inhibition of glucagon release exerted by glucose.”

“Intravenous infusion of arginine elicited increments of plasma immunoreactive glucagon (IRGI) in both groups, and this response was slightly exaggerated in the patients with diabetes.”

“However, the mean peak percent rise in glucagon concentration after oral arginine was significantly lower than that after intravenous arginine (62% +/- 25% versus 479% +/- 176%, respectively, p = 0.04).”

“Plasma glucagon after an arginine load was significantly higher in patients than in controls.”

“After administration of L-arginine in the acute renal failure a significantly higher increase of the glucagon level, but a significantly lower increase of the insulin concentration could be observed than in healthy persons.”