Possible Interaction: Arginine and Gentamicin

“The combination of gentamicin + l-arginine was active against most of the tested strains with the notable exception of CoNS for which no potentiation was observed.”

“Moreover, although gentamicin local treatment alone showed poor efficacy in a clinically relevant in vivo model of catheter-related infection, gentamicin supplemented with L-arginine led to complete, long-lasting eradication of S. aureus and E. coli biofilms, when used locally.”

“The urinary levels of gentamicin were significantly increased in rats treated with L-arginine or D-arginine compared to those treated with gentamicin.”

“In animals treated with gentamicin together with L-arginine , there was a significant amelioration in the BUN and creatinine levels.”

“Gentamicin increased both [3H]thymidine incorporation into DNA and viable cell number; when L-arginine was added together with gentamicin , this abolished the effect of gentamicin on mesangial cell proliferation.”

“Gentamicin induced a reduction of the planar surface area of cultured rat mesangial cells; cell treatment with gentamicin plus L-arginine significantly decreased the contractile effect of gentamicin.”

“In addition to polymers of cationic amino acids (lysine, ornithine, arginine and histidine), polymers of neutral (asparagine) and acidic (aspartic and glutamic acid) amino acids also exhibited inhibition of the membrane binding of gentamicin.”

“In response to GM , renal MDA level increased in male and female rats (P < 0.05), and in the presence of GM + L-arginine , the level of MDA significantly decreased in both genders (P < 0.05).”