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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Fluorouracil
Research Papers that Mention the Interaction
“ L-Arginine induces the NO production and potentiate the anticancer effect of 5-FU.”
“Finally, our predictive simulation results also showed that the addition of l-arginine supplementation to the intermittent 5-FU therapy reduced the time of the tumor eradication and the number of iterations for 5-FU treatment.”
“RESULTS 5- U co mbined with L-A rg co uld inhibit the tumor growth apparently.”
“Altogether, these findings clearly suggest that L-arginine inhibits cell death induced by 5-FU in HUVECs through attenuating the adverse effects of 5-FU, while it does not do so in breast cancer cells.”
“Combinations of L-arginine and 5-FU increased cell survival in HUVECs but induced cell death in MDA-MB-468 cells.”
“Our findings indicated that l-arginine increased the anticancer effect of 5-FU in BT-20 and MCF-7 cell lines.”
“The aim of this study was to evaluate if a combination therapy of l-arginine with 5-fluorouracil (5-FU) can alter the effect of this chemotherapy drug on breast cancer cells.”
“ l-arginine increased 5-FU effect on BT-20 and MCF-7 cell lines by reducing cell viability and increasing apoptosis and NO production.”
“ L-Arg may be a good adjuvant for chemotherapy with 5-FU.”
“We observed the expression of inducible nitric oxide synthase (iNOS) and apoptosis of cells induced by 5-FU with L-Arg added to the medium.”
Mechanism of apoptotic effects induced by 5-fluorouracil on human liver carcinoma Bel7402 cell line.“Supplementation with 50 mg/d of l-arginine decreased the weight loss generated by 5-FU in Wistar rats.”
l-arginine minimizes immunosuppression and prothrombin time and enhances the genotoxicity of 5-fluorouracil in rats.“The results suggest that daily supplementation with 295 or 458 mg L-arginine attenuates the side effects of 5-FU , including thrombocytopenia and neutropenia, and modulates IgA production.”
“In conclusion L-arginine supplementation potentially reduces the jejunal lesions and DNA damage caused by 5-FU.”
Supplementation with L-Arginine Decreases Jejunal Lesions and Micronucleus Formation Induced by 5-Fluorouracil in Rats.“ L-arginine attenuated effectively some biochemical and histological changes in 5-FU nephrotoxicity.”
“ L-arginine improved glomeruloscelerosis, degeneration of convoluted tubules and interstitial fibrosis in 5-FU treated animals.”
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