Possible Interaction: Arginine and Fluorides

“Most new therapies try to enhance the effect of fluoride by adding other potentially active ingredients to the formulation, such as calcium, phosphate, stannous, xylitol, and arginine.”

“These studies demonstrated that the arginine plus fluoride formula , compared to regular fluoride toothpaste, consistently reduced new cavities by up to 20% at 2 years [Kraivaphan, 2013; Li et al., 2015] and reversed early caries lesions by approximately half in 6 months [Yin et al., 2013a, b; Srisilapanan, 2013].”

“Hence, we propose that fluoride and arginine have a potential synergistic effect in maintaining an eco-friendly oral microbial equilibrium in favor of better caries management.”

“Moreover, we found that combinatory use of arginine with fluoride could better enrich alkali-generating Streptococcus sanguinis and suppress acidogenic/aciduric Streptococcus mutans, and thus significantly retard the demineralizing capability of saliva-derived oral biofilm.”

“Thus, the current study did not identify evidence for any strategy to effectively be used as a substitute … fluoride, but identified some consistent evidence derived from the use of prebiotic strategies (primarily from use of arginine combined with calcium) to support their … boost the mechanism of action of fluoride.”

“Conclusions: When used in combination with a calcium compound and fluoride, arginine potentially provides a superior anti-caries effect compared with matched formulations of fluoride alone.”

“The meta-analysis results (n = 7 studies) demonstrated a synergistic effect of arginine when used in conjunction with fluoride on early coronal and root caries compared with placebo or fluoride alone.”

“CONCLUSIONS Ar inine pr omoted enamel fluoride uptake when used in combination with flu oride, t hereby contributing to resistance of enamel to carious demineralization.”

“When used in combination with fluoride, arginine significantly increased fluoride uptake compared with fluoride alone (p<0.05).”

“Here, we hypothesize that arginine may augment the ecological benefit of fluoride by enriching alkali-generating bacteria in the plaque biofilm and thus synergizes with fluoride in controlling dental caries.”

“Recent clinical trials have shown that oral hygiene products containing both fluoride and arginine possess a greater anticaries effect compared with those containing fluoride alone, indicating synergy between fluoride and arginine in caries management.”

“Taken together, we conclude that the combinatory application of fluoride and arginine has a potential synergistic effect in maintaining a healthy oral microbial equilibrium and thus represents a promising ecological approach to caries management.”

“We found that arginine synergized with fluoride in suppressing acidogenic S. mutans in both planktonic and biofilm cultures.”

“As the mechanisms of action of arginine and fluoride are highly complementary, a next-generation dentifrice has been developed, which combines arginine, an insoluble calcium compound, and fluoride, and has been clinically proven to provide superior caries prevention.”

“As the mechanisms of action of arginine and fluoride are highly complementary, a new dentifrice, which combines arginine with fluoride, has been developed and clinically proven to provide superior caries prevention.”

“ R is strongly reduced by the presence of small amounts of fluoride in the demineralizing system.”