Possible Interaction: Arginine and Estradiol

“The levels of 17β-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice.”

“While estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK, progesterone inhibits arginine transport and CAT-1 via both PKCα and ERK1/2 phosphorylation, an effect that predominates over estradiol.”

“ Estradiol lowers the operating point for osmoregulation of arginine vasopressin and thirst and increases plasma volume.”

“Consistent with our previous findings, L-Arg elicited an inhibitory action on the production of oestradiol (P< 0.05).”

“Serum and urinary hormone profiles determined serially during AG-HC therapy revealed that all measured serum androgens and … were significantly lowered by AG-HC treatment; however, specific hormones, including free testosterone, di-hydrotesterone, estrone, and estradiol were suppressed to a … degree in responders ( R ) as compared with nonresponders (NR).”

“RESULTS Oe tradiol tr eatment reduced L-A rg co ncentration (p<0.01), iNOS mRNA (p<0.01) and protein (p<0.001) expression, level of RhoA (p<0.05) and AT1R (p<0.001) protein.”

“The volume fraction occupied by arginine vasopressin immunoreactive material was significantly increased in both nuclei in the animals treated with estradiol compared to the animals injected with vehicle.”

“Results of Experiment I indicate that the efficacy of EB for suppressing LH, but not FSH, secretion is increased significantly in R rats.”

“Results of Experiment III indicate a delayed, but more prolonged, suppression of LH secretion by EB in R rats when compared to C rats.”

“These results suggest that the B36 and DNA binding domains of R are related and strengthen the hypothesis that R has different external structures when activated or nonactivated and when bound to an anti-estrogen or to estradiol.”

“Although DNA values for the … P higher than EB, R … EB or EB plus P. R alone at either level did not change RNA from the no treatment group, but … levels of R in association with EB plus P significantly reduced RNA in relation to the appropriate control groups.”