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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Epoprostenol
Research Papers that Mention the Interaction
“CONCLUSIONS: Exposure to intravenous formulations of epoprostenol in glycine and arginine caused increased cell death and ciliary cessation in bronchial epithelial cells.”
Local Effects of Two Intravenous Formulations of Pulmonary Vasodilators on Airway Epithelium“The anti-aggregatory action of L-arginine is potentiated by prostacyclin and by M&B22948, a selective inhibitor of the cyclic GMP phosphodiesterase, but not by HL725, a selective inhibitor of the cyclic AMP phosphodiesterase.”
“However, in the presence of a subthreshold concentration of prostacyclin (0.1 nm) or of M & B 22948 (1 μm), a selective inhibitor of guanosine 3′:5′‐cyclic monophosphate (cyclic GMP) phosphodiesterase, l‐arginine caused concentration‐dependent inhibition of aggregation induced by all of these aggregating agents.”
“We found that in rats treated with L-arginine , the amount of prostacyclin , measured as 6-keto-PGF1 alpha, was significantly increased.”
Nitric oxide modulates prostacyclin biosynthesis in the lung of endotoxin-treated rats.
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