Possible Interaction: Arginine and Epinephrine

“ Epinephrine alone did not alter HGH secretion, but HGH responses after arginine were inhibited to the same extent as in experiments in which only FFA was increased.”

“In a unique particle counting apparatus, epinephrine initially triggered the formation of small platelet aggregates composing of 10-1000 cells from both R and NR, but the aggregates became larger (4600 > cells) only in platelets from R. Thus, platelets from NR lack the ability to form larger aggregates.”

“These studies demonstrate that EPI inhibits AIR to arginine over a wide range of glucose levels, but that the B-cell-stimulating effect of hyperglycemia can obscure this inhibition.”

“ Adrenaline and noradrenaline (and not isoproterenol) also reduced vessel tension in the presence of L-Arginine.”

“ R and BBCr+R significantly decreased glycaemia after adrenalin load (R: 8.6 +/- 1.8 mmol/l vs 15.4 +/- 3.2 mmol/l; p=0.004; BBCr+R: 9.6 +/- 2.4 mmol/l vs 15.0 +/- 4.4 mmol/l; p=0.04).”

“Amplification by S 21403 of glucose‐induced insulin secretion in diabetic GK β‐cells with restoration of first‐phase response, a strong synergistic interaction with arginine and marked inhibition by adrenaline , make it a prime candidate for successful oral antidiabetic agent.”

“ l‐arginine had an equivalent effect to L‐NAME and increased the chronotropic effect of epinephrine in cholestatic rats but not in control animals.”

“Surprisingly L-arginine was as effective as L-NNA and increased the chronotropic effect of epinephrine in cholestatic rats but not in sham-operated animals.”

“ Epinephrine abolished the insulinotropic effect of arginine without altering the rise in 86Rb+ efflux triggered by the amino acid.”

“ Epinephrine abolished the insulinotropic effect of arginine alone or with theophylline.”