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“NOS inhibitors (S‐ethylisothiourea and S‐isopropylisothiourea), a NO scavenger (2‐(4‐carboxyphenyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide), DA , and cocaine blocked the L‐Arg effect.”
“ L-Arginine but notD-arginine increased the striatal content of dopamine in pre- and postischemia whereas it lowered the levels of dopamine and 3-methoxytyramine induced by ischemia.”
British journal of pharmacology • 2000 | View Paper
“ L-ARG (50 mM–100 mM), but not D-arginine (100 mM) nor L-citrulline (100 mM), produced a biphasic effect on dopamine efflux with an initial small reduction, followed by a large sustained increase.”
“The … of DA in the striatal extracellular fluid (ECF) increased …–15-fold in the presence of L-Arg in the perfusate as compared with that of the controls (DA level in drug-free perfusate varied from 0.050 ± 0.009 to 0.092 ± 0.023 pmol 10 μUl−1).”