Possible Interaction: Arginine and Dinoprostone

“Individual formulations had an effect on PGE2 WAI during the 8 hours following treatment, resulting in significantly lower WAI in standard ibuprofen: ibuprofen arginine 18.4%, solubilized ibuprofen capsule 18.4%, and standard ibuprofen 11.6%.”

“ L-Arg and LPS enhanced PGE2 output by tissues but did not influence NO production.”

“… PGE2 for 1 and … number of PGE2 R , by co-ordinate suppression of the EP2 R and EP3 R. Desensitization of EP2 R and EP3 R for 1 hr …, whereas selective down-regulation of EP2 R alone by PMA for 1 hr had no effects on U937 cell migration.”

“As has been shown … rat, physiologic levels of L-arginine (0.01 mM) … LPS-induced PGE2 secretion relative to the response in medium containing standard L-arginine concentration (1.2 mM); however, unlike … KC, the human's cytokine response to LPS was not downregulated by this enhanced PGE2 release.”

“Conversely, PGE2 inhibited the AIR to arginine in diabetics (PGE = 28 +/- 5 microunits/ml, control = 39 +/- 7 microunits/ml, n = 7, p less than .05), but not in normal subjects (PGE = 74 +/- 7 microunits/ml, control = 80 +/- 14 microunits/ml, n = 5, p = ns).”

“inhibited the production of prostaglandin E2 and cyclic adenosine 3׳,5׳-monophosphate, while promoted the secretion of arginine vasopressin.”

“Moreover, l-arginine enhanced productions of both the latter produced TNF-alpha and PGE2 from burnt macrophages, and the expressions of TNF-alpha and COX-2 were improved significantly, while l-NMMA did reverse ways.”

“Conversely, L-arginine (300 mg/kg SC) increasedNOx by 39 +/- 7% (P < 0.01) and PGE2 by 78 +/- 6% (P < 0.001).”

“These findings suggest that the interaction between the α-carboxylic acid of PGE2 and the arginine residue of the receptor regulates the selectivity of the G protein coupling.”

“infusion of PGE2 (79 ng ml−1, 30 min) was enhanced by infusion of l‐NAME and was inhibited by l‐arginine and sodium nitroprusside.”