Possible Interaction: Arginine and Diazepam

“We also showed that the effects of diazepam on leukocyte–endothelium … are mediated by nitric oxide (NO), since prior treatment with l-arginine (precursor of NO) partially … the inhibitory effects of diazepam ; conversely, pretreatment with L-NAME (false substrate of the NO synthase) somewhat potentiates the effects of diazepam.”

“ L-arginine , the precursor of NO, increased the protective effect of both phenobarbitone and diazepam.”

“The data further suggest that the duration of action of L-arginine is considerably short and that L-arginine has an additive anticonvulsant action with diazepam. [”

“The effect produced concurrently by L-arginine and diazepam post-treatment was much greater than that produced by these agents independently.”

“The combined effect of diazepam and L-arginine post-treatment was much greater than that produced by these agents independently.”

“The data further indicate that the duration of action of L-arginine is considerably short and has an additive anticonvulsant action with diazepam.”

“The incubation of whole blood with diazepam led to significant changes in PMN free glutamine, aspartate, glutamate, ornithine, arginine , citrulline, taurine and methionine as well as branched chain and neutral amino acid concentrations.”

“ L-Arginine , when administered with diazepam , was found to inhibit tolerance as well as withdrawal hyperexcitability.”