Possible Interaction: Arginine and Dexamethasone

“The demonstration that L-arginine and vitamin C can partially offset the effects of dexamethasone on microvascular arterioles suggests the potential clinical usefulness of these agents for the reduction of glucocorticoid-induced hypertension.”

“Patients with DM had increased ammonia, citrulline, urea, uric acid, and ornithine, mainly in the RBCs, whereas the level of arginine was significantly lower in men with type 2 DM.”

“ Dexamethasone treatment (6 mg/day for 60 h) markedly enhanced the insulin response to arginine in subjects with high response (+99% 0–30 min) but failed to affect the subjects with low response (+4% 0–30 min).”

“Furthermore, in high but not in low insulin sensitivity, dexamethasone reduced the glucagon response to arginine (p = 0.043).”

“In HuH-7.MCAT-1 cells l-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone , and hepatocyte growth factor also increased l-arginine uptake along with cellular DNA synthesis.”

“In all cases, there was a linear log-log correlation between R and DM.”

“Nitrite accumulation was accompanied by cell damage, which was increased by L-arginine and inhibited by NG-monomethyl-L-arginine (L-NMMA) and dexamethasone.”

“Interestingly, the insulin release during arginine load was significantly decreased in NT and IT as well as in DM patients.”

“ Dexamethasone not only suppressed by 50% the spontaneous Fc epsilon R expression on U937 cells but also completely inhibited the enhancement of their Fc epsilon R expression on U937 cells induced by PMA, IFN-gamma or H107.”

“ Dexamethasone administered to healthy subjects in a daily dose of 3 mg over a four day period caused significant increases in alanine and methionine levels (26%) as well as a rise in arginine.”