Possible Interaction: Arginine and Dactinomycin

“The stimulated arginine uptake could be blocked by pretreatments with cycloheximide and actinomycin D or co-treatment with valsartan, an antagonist specific for Ang II receptor subtype-1.”

“These results indicate that the tumor cell growth inhibition caused by a‐AD originates from the depletion of the essential nutrient l‐arginine , and that the resulting block of the polyamine‐biosynthesis pathway is involved in part in the inhibitory mechanism.”

“We report here that the sensitivity of the synthetase to activation by arginine increases markedly after intraperitoneal administration to mice of inhibitors of nucleic acid and protein synthesis, including actinomycin D , aurintricarboxylic acid, cycloheximide, emetine and puromycin.”

“ Actinomycin D blocked the induction of renin and arginine esterase.”

“Abstract Acetylornithine δ-transaminase, an enzyme of the arginine pathway, is inducible by arginine in a mutant strain of Escherichia coli W. Rifampin, an inhibitor of initiation of transcription, does not prevent the induction of this enzyme by arginine, whereas actinomycin D completely eliminates the inductive effect of arginine.”