Possible Interaction: Arginine and Cyclosporine

“Animal studies have shown that dietary supplementation with arginine and lipids containing the &ohgr;-3 and &ohgr;-9 fatty acids prolong allograft survival in animals receiving a short course of low-dose cyclosporine.”

“Also, the acute glucagon response to arginine during hyperglycemia declined less in the FK-506 (28%) and CsA groups (29%) compared with controls (48%) (P<0.05) indicating a defect in the pancreatic beta cell-alpha cell axis.”

“The lower percentage of increase of insulin release after arginine stimulation observed in the FK-506 and CsA groups as compared with controls (754%+/-100, 644%+/-102 vs. 1191%+/-174) (P<0.03 and 0.02, respectively), suggests a reduced beta cell secretory reserve in both treated groups.”

“In contrast, administration of l-Arg ameliorated the effect of CsA on H+ excretion.”

“More infiltrating inflammatory cells were detected at an early stage of tumor rejection in rats treated with arginine plus cyclosporine than in cyclosporine-treated rats.”

“The antagonistic effect between arginine and cyclosporine on immune suppression is worthy of further investigation in organ transplant patients.”

“The supplement of L-arginine (1 mM) promoted NO production that enhanced EPC proliferation and attenuated the effect of CsA on EPC proliferation and apoptosis.”

“In this study we investigated whether the PPARgamma ligand rosiglitazone R ) enhances in vitro the immunosuppressive effects of cyclosporine A (CsA).”

“Low-dose CsA combined with R was significantly more powerful than either high-dose CsA alone or R alone in suppressing IL-2 release, arresting the T cell cycle, and blocking the growth of activated T cells.”

“The L65R(TM1), T199R(TM3), I306R(TM5), or F343R(TM6) mutations were introduced into the P-gp mutant L339C(… carried out in the presence of various concentrations of vinblastine, cyclosporin A, or rhodamine B. The presence of arginine residues reduced the …, T199R, and I306R), cyclosporin (I306R and …–60-fold.”

“Furthermore, the observed increase in sodium excretion could indicate that L-arginine counteracts the antinatriuretic effect of cyclosporin.”

“Furthermore, l-arginine pretreatment with cyclosporine A (5 mg/kg) significantly reversed the protective effect of cyclosporine A. However, l-nitro-arginine methyl ester (l-NAME; 10 mg/kg) pretreatment potentiated the protective effect of cyclosporine A (5 mg/kg).”

“Coadministration of trapidil + l-arginine significantly ameliorated the toxic effect of CsA , but did not differ significantly from the effect of trapidil alone.”