Possible Interaction: Arginine and Cyclophosphamide

“The addition of rituximab R ) to standard CHOP ( cyclophosphamide , doxorubicin, vincristine, and prednisone) chemotherapy has altered the significance of previously recognized prognostic factors.”

“The addition of rituximab R ), an anti-CD20 antibody, was shown to increase the effectiveness of cyclophosphamide , doxorubicin, vincristine, and prednisone (CHOP) chemotherapy in patients with diffuse large B cell non-Hodgkin lymphoma (DLBCL) [13].”

“ CP treatment tended to reduce the plasma levels of l‐arginine in CT26‐bearing mice and significantly increased the number of tumor‐infiltrating CD8+ T cells.”

“Importantly, additional supplementation of l‐arginine significantly increased the number of cured mice that were treated with CP and anti‐PD‐1 antibody.”

“Supplementation of l‐arginine showed a tendency to augment the efficacy of cyclophosphamide (CP).”

“ Arg alleviated the decrease of average daily gain (P < 0.05) induced by CY challenge from days 21 to 28.”

“ Arg increased the delayed-type hypersensitivity reaction (P < 0.05), and attenuated the decrease of bovine serum albumin antibody level caused by CY treatment (P < 0.05) on day 28.”

“Both activities of macrophages from mice pretreated with OK-432 and cyclophosphamide were enhanced with increasing concentrations ofl-arginine (0.125–1 mM) in the culture medium.d-Arginine, however, did not substitute forl-arginine.”

“SMT but not L-arginine produced marked inhibition of CP induced bladder damage.”