Possible Interaction: Arginine and Corticosterone

“In ovo administration of high dose CORT significantly suppressed the growth rate from 3weeks of age and increased the frequency of aggressive behaviors, and the dosage was associated with elevated plasma CORT concentrations and significantly downregulated hypothalamic expression of arginine vasotocin (AVT) and corticotropin-releasing hormone (CRH).”

“Additionally, arginine depletion significantly increased corticosterone concentrations, which negatively correlated with time spent floating.”

“In stressed and unstressed animals, the number of androgen receptors and arginine vasopressin-expressing neurons in both of these nuclei correlated negatively with corticosterone concentrations in plasma and Fos levels in the paraventricular nucleus.”

“Exposure to an acute social defeat elicits increases in plasma adrenocorticotrophic hormone and corticosterone levels, peaking at 15 and 30 min, respectively, and enhances corticotrophin‐releasing factor (CRF) mRNA, but not arginine vasopressin (AVP) mRNA within the medial parvocellular division of the hypothalamic paraventricular nucleus.”

“ L-arginine greatly impaired the nicotine-induced hormone responses and reversed the L-NNA elicited enhancement of the nicotine-evoked ACTH and corticosterone response.”

“ L-arginine prevented the rise in SBP produced by orticosterone (131 ± 3 to 131 ± 2 mmHg, control versus day 10) but D-arginine did not (129 ± 3 to 142 ± 4 mmHg on day 8, P < 0.01).”

“ L-Arginine significantly decreased both basal and ACTH-stimulated corticosterone production.”

“ L-arginine also significantly reversed the L-NAME-evoked increase in the CRH-induced ACTH and corticosterone secretion.”

“Pretreatment with L-arginine , a substrate for NOS, slightly diminished the CRH-induced ACTH response and considerably reduced the corticosterone response.”

“ Corticosterone also decreased metabolism of arginine to ornithine in the later wound.”

“ L-arginine , given in higher doses (120-150 mg/kg ip) 15 min prior to icv carbachol (2 micrograms), markedly diminished the carbachol-induced rise in corticosterone secretion.”