Possible Interaction: Arginine and Clavulanic Acid

“Furthermore, some amino acids such as arginine and ornithine, could serve as potential precursors to increase clavulanic acid yield.”

“Addition of arginine to the cultured mutant further improved clavulanic acid production giving a greater than 2-fold increase over wild type, suggesting that arginine became limiting for biosynthesis.”

“Ornithine and arginine (5 to 20 mM), but not glutamic acid or proline, exerted a concentration-dependent stimulatory effect on the biosynthesis of clavulanic acid in both resting-cell cultures and long-term fermentations of Streptomyces clavuligerus.”