Possible Interaction: Arginine and Citrulline

“Plasma arginine was suppressed significantly below baseline with a reciprocal increase in citrulline during the sampling period.”

“However, levels of citrulline in MELAS patients were significantly lower than in controls, and there was a clear inverse correlation between arginine and citrulline levels in these patients.”

“Furthermore, a significant inverse relationship was observed between changes in lactate and L-citrulline concentrations after L-ARG load (r = -0.84, p = 0.009).”

“Oral supplementation of L-arginine significantly increased plasma L-citrulline , which indicated enhancement of NO production.”

“ L-Citrulline levels were significantly increased during infusion of L-arginine , and the increase was significantly lower in the women with preeclampsia.”

“The rise in L-citrulline may be related to competition with L-arginine for the same cell membrane transport mechanism and to stimulation of the urea cycle.”

“ Citrulline slightly modulates NO production in vivo and in vitro, suggesting a possible action through modulation of arginine metabolism in macrophages rather than a direct transductional effect.”

“BACKGROUND Chronic supplementation with L-citrulline plus L-arginine has been shown to exhibit anti-atherosclerotic effects.”

“ l-Citrulline treatment significantly increased plasma l-arginine and l-citrulline concentrations and increased ASL protein expression in hyperoxia.”

“ l-arginine plus l-citrulline , either alone or in combination with antioxidants, caused a marked improvement in endothelium-dependent vasorelaxation and blood flow, dramatic regression in atheromatous lesions, and decrease in superoxide production and oxidation-sensitive gene expression.”