Possible Interaction: Arginine and Cisplatin

“Thus, the combination of arginine deprivation and cisplatin function in concert to kill tumor cells which do not express ASS without added toxicity to normal cells.”

“In addition, it was found that arginine supplementation could inhibit the proliferation ability of HT29 cells in vitro, and a synergistic effect existed between arginine and cisplatin.”

“In addition, cell-free MK mRNA expression was significantly correlated with inhibitory rate of cisplatin ( R = −0.72, P < 0.01).ConclusionsMeasurement of cell-free MK mRNA levels in effusion supernatant yields a high diagnostic accuracy and a potential predictive value.”

“The combination of arginine butyrate and cisplatin resulted in a concentration-responsive increase in cisplatin-DNA adduct formation in PC-3 cells and an overall increase in cisplatin-DNA adduct formation in three other human cancer cell lines.”

“Diethyldithiocarbamate, potassium cyanide (KCN), sodium thiocyanate, L-methionine, N-acetyl-L-cysteine, 2-aminoethanethiol, L-cysteine, L-lysine, L-histidine, and L-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum(II)-protein binding in the in vitro model system.”

“ CDDP + AS IV co-treatment significantly altered two pathways in the blood (biosynthesis … in the urine (phenylalanine metabolism; phenylalanine, tyrosine, and tryptophan biosynthesis; arginine biosynthesis; arginine and proline metabolism; and histidine metabolism), and five pathways in the kidneys (…; arginine and proline metabolism; and D-glutamine and D-glutamate metabolism).”

“The expression level of arginine immunoreactivity was reduced as a function of the dose of cisplatin used.”

“Furthermore, L-arginine shows nephroprotective effects and might be useful in improving the therapeutic index of cisplatin.”

“ L-arginine significantly attenuated the oxidative stress and nephrotoxic effect of cisplatin.”

“In addition, L-arginine may be a beneficial remedy for CDDP-induced renal toxicity, and could be used to improve the therapeutic index of CDDP.”

“The findings of this study suggest that L-arginine can attenuate kidney injury that is produced by CDDP treatment.”

“… L-arginine (70 mg/kg/d p.o in drinking water … the CDDP injection) significantly ameliorated the renotoxic effects of CDDP , as judged by restoring the normal responses of isolated bladder rings to Ach, and … of renal function indices, which included serum urea and creatinine concentrations and kidney weight.”

“ L-Arginine also reduced apoptosis and necrosis in RMC that were incubated with etoposide and cis-platinum.”