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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Chlorzoxazone
Research Papers that Mention the Interaction
“ Chlorzoxazone was not a substrate for iNOS but … potent competitive inhibitor with respect to L-Arg with Ki = 3.3 ± 0.7 μM. The binding of chlorzoxazone to iNOS and human and rat … microsomal cytochrome P-450 induced a high spin, type I spectra, which was reversed by imidazole.”
Characterization of Inducible Nitric-oxide Synthase by Cytochrome P-450 Substrates and Inhibitors
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