Possible Interaction: Arginine and Chlortetracycline

“A more detailed investigation of the new peptides could demonstrate that the number of the following amino acids was reduced in the peptide chains after chlortetracycline : leucine, valine, serine, arginine , and lysine.”

“Within a 12.5-hr incubation period at … following antibiotic concentrations/milliliter were found to suppress arginine desimidase activity: 0.… oxytetracycline or chlortetracycline , 0.005 unit penicillin, 0.5 unit nisin, 0.075 μg oleandomycin, 0.… bacitracin, 0.01 μg streptomycin, 7.5 units polymyxin, and 0.1μg neomycin.”

“Decarboxylation of tryptophan was not consistently inhibited by chlortetracycline, but decarboxylation of aspartic acid, glutamic acid, and arginine was markedly reduced in the presence of chlortetracycline.”