Possible Interaction: Arginine and Captopril

“ L-Arginine increased the effect of captopril , whereas L-NMMA showed a competitive antagonism for the effect of captopril on coronary flow in the isolated rat heart.”

“ Captopril pretreatment attenuated the rise in GFR following arginine infusion in normal subjects.”

“… captopril produced a … FF in R whereas these indices did not change in NR; it was found that IF and GFR decreased in R whereas IF increased and …; a significant correlation was observed between delta IF and delta GFR in R (r = 0.834, p less than 0.05).”

“ L-arginine added into the perfusate potentiates the effect of captopril on the NO signaling pathway.”

“A … vivo captopril treatment … L-arginine administration significantly decreased the levels of MRCC radicals in the isolated myocardium (.QH from 2.61 to 1.72 and .FeS, from … 0.46 under normoxia; .QH from 4.35 to 2.66 and .FeS1 from 1.93 to 1.35 during ischemia).”

“Conclusion: Combined administration of captopril and L-arginine has a synergistic, protective effect on heart function and coronary flow that may be mediated by enhanced NO production.”

“Addition of L-NAME or L-arginine in the perfusate augmented or attenuated the vasoconstriction responses in the Cap treated group.”

“The attenuated vasoconstrictor effect by L-arginine was greatly augmented by captopril , suggesting that captopril improves the function of resistance of vessels by mediating endothelial cells.”