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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
Research Papers that Mention the Interaction
“Although plasma levels of CGRP decreased significantly in controls following L-arginine infusion, those of CGRP did not change in migraine patients.”
[Autonomic nervous activity in migraine].“In cultured trigeminal neurons, L-arginine upregulated the expression of CGRP , and this effect was diminished by cilnidipine (N-type calcium channel blocker) while not by mibefradil (L-type calcium channel blocker).”
CGRP Modulates Orofacial Pain through Mediating Neuron-Glia Crosstalk“5 The release of CGRP evoked by ETX was enhanced by L‐arginine by 43% and inhibited by Nω‐nitro‐L‐arginine (L‐NOARG) and methylene blue by 37% and 38%, respectively.”
“Pretreatment with L-arginine , but not D-arginine, reverses these effects of CGRP antagonism.”
“ CGRP , in a concentration-dependent manner, enhanced the release of nitrite (a stable oxidation product of NO) and the formation of L-citrulline from L-arginine caused by IL-1 beta.”
“In contrast, CGRP impaired the plasma insulin responses to both glucose (7 mg/min; P less than 0.001) and arginine (8.5 mg/min; P less than 0.001), and inhibited the arginine-induced increase in plasma glucagon concentrations (P less than 0.001).”
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