Possible Interaction: Arginine and Budesonide

“… corticosteroid budesonide inhibited the TNF-alpha release dose dependently with an ….13 nM. The simultaneous administration of 10 microM R ,R-glycopyrrolate reduced the IC(50) to 0.13+/-0.03 nM. Finally, R,R-… the triple combination with budesonide and rolipram in the reduction of TNF-alpha release.”

“In the presence of L-arginine (100 µg/ml), a NO donor increasing peroxynitrite production, LACL increased 3–5 times compared with baseline, but budesonide dose-dependently reduced LACL (25.5–59.6%).”