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Last Updated: 2 years ago

Possible Interaction: Arginine and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

The pretreatment ADMA and l-arginine levels were significantly higher, and plasma nitrite plus nitrate (NOx) levels were lower than those in the control group.
There was a significant positive correlation (P < 0.01) between ADMA and l-arginine and a negative correlation between ADMA and NOx levels in patients and controls.
The Journal of clinical endocrinology and metabolism  •  2005  |  View Paper
L-Arginine (10(-3) mol/L) prevented the contractions by L-NMMA and ADMA but did not change contractions induced by AG and MG.
Stroke  •  1999  |  View Paper
Despite multiple studies, the mechanisms of reducing the level of ADMA , which would allow to inhibit the progression of cardiovascular diseases and effective treatment, e.g. by means of L-arginine supplementation or medicines which are lowering ADMA levels, are still unclear.
International angiology : a journal of the International Union of Angiology  •  2018  |  View Paper
ADMA acts as an endogenous, nonselective, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) and may limit l-arginine supply from the plasma to the enzyme via reducing its transport by cationic amino acid transporters.
Neurochemical Research  •  2016  |  View Paper
Their use is associated with increased risk of heart attacks caused by blocking COX‐2 in the vasculature and/or kidney, with our recent work implicating the endogenous NOS inhibitor asymmetric dimethylarginine ADMA ), a cardiotoxic hormone whose effects can be prevented by L‐arginine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  2016  |  View Paper
Statins, renin-angiotensin-aldosterone system inhibitors, blood glucose lowering agents, insulin sensitizers, beta-blockers, estrogen replacement therapy, antioxidants, complex B vitamins, L-arginine and acetylsalicylic acid have been evaluated for their ability to reduce ADMA levels or inhibit its actions.
Current medicinal chemistry  •  2015  |  View Paper
As the common substrate for hArg and ADMA, Arg may play a key role in the biosynthesis and homeostasis of hArg and ADMA , two putative antagonists.
Amino Acids  •  2015  |  View Paper
Asymmetric-dimethylarginine ADMA ) competes with L-arginine for each of the three isoforms of nitric oxide synthase: endothelial; neuronal; inducible.
World journal of gastroenterology  •  2015  |  View Paper
Besides, ADMA may play a significant role in the level of NO, which is produced by arginine.
Inflammation  •  2014  |  View Paper
Recently, it became clear that endogenous levels of asymmetric dimethylarginine ADMA ), a competitive inhibitor of L-Arginine metabolism by NOS, may determine an individual's response to L-arginine supplementation.
Alternative therapies in health and medicine  •  2014  |  View Paper
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