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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment.”
Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity“Twenty day treatment with 3 g of l-arginine and 75 mg of acetylsalicylic acid daily resulted in a decrease of the level of lipid peroxidation products and augmentation of α-1-antitrypsin activity.”
“Results indicate a statistically significant blood pressure reduction (negative mean area between … blood pressure profiles obtained before and after aspirin administration) only when ASA was given seven to nine hours after awakening ( R x 2 ; P = .012, .003, and .006 for systolic, mean arterial and diastolic blood pressure, respectively).”
“ Arginine stimulated insulin … increased after ASA (p<0.01 at 15 min; p<0.05 at 30 min; p<0.05 at 45 min), whereas glucose values were … than under basal conditions at all times, with significant differences at 105 (p<0.02) and 120 (p<0.05) min.”
“In addition, the fall in plasma FFA concentrations during arginine infusion was significantly less after ASA than levels observed without ASA (--262 +/- 100 microEq/l vs --35 +/- 57 microEq/l, p less than 0.02).”
“Furthermore, the DT + ARG group exhibited significantly enhanced plasma ASA activity (P < 0.05).”
“Addition of L-arginine to aspirin treatment completely prevented aspirin-induced endothelial dysfunction but defective response to sodium nitroprusside persisted.”
“Contrary to our expectation, co-administered L-arginine protected aspirin induced endothelial dysfunction and ruled out the limitation of aspirin use in L-arginine consumers.”
“In the POA, a treatment with ASA or L-NAME antagonized the inhibition of drinking behaviour caused by injection of the highest doses of L-arginine.”
Interleukin-1 inhibits drinking behaviour through prostaglandins, but not by nitric oxide formation.“The addition of L-arginine to the solution in the Krebs-Henseleit solution plus aspirin group increased the production of hydroxyl radicals from 0.32 +/- 0.18 nmol/gm per 3 minutes to 0.75 +/- 0.33 nmol/gm per 3 minutes (p = 0.03).”
“The prolonged half-life of nitric oxide may explain the increased levels of cyclic guanosine monophosphate seen in the group perfused with Krebs-Henseleit solution plus aspirin plus L-arginine.”
“The synergism between aspirin and arginine may be caused in part by the scavenging of hydroxyl radicals.”
“Significant reductions in R occurred 25 min after exposure to acidified aspirin.”
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