Possible Interaction: Arginine and Aspartate

“In healthy volunteers, a chronic oral treatment with 30 g/day arginine aspartate is followed by a decrease in IGF‐1 and IGFBP‐3 secretions.”

“A significant increase in urea and aspartate transaminase levels in patients receiving active L-arginine treatment was observed.”

“ Arginine supplementation significantly enhanced the amount of collagen deposited into a standardized wound as assessed by the ….32 nmol/cm graft in controls vs 17.57 +/- 2.16 nmol/cm in the arginine aspartate group , [p = 0.028] and vs 23.85 +/- … hydrochloride group [p less than 0.001]).”

“By the same token, 5 and 20 minutes after completion of the test run, blood lactate levels were significantly lower in the group receiving arginine aspartate.”

“Substitution of the aspartate residue by alanine or arginine results in significant reduction of antibody binding affinity.”

“ Arginine led to significant increases in PMN arginine, ornithine, citrulline, aspartate , glutamate and alanine concentrations as well as increased H2O2-generation and MPO activity while O2−-formation was decreased.”

“ Arginine aspartate provokes a significant increase between 1 h and 4 h of alcoholemic disparition slope, when rapported to body weight: mg/kg/h (p < 0,02), and ethyloxydation coefficient: mg/kg/h (p < 0,05).”

“Supplementation of aspartate or malate increased renal levels of L-arginine and NO and attenuated hypertension in SS rats.”

“ l‐Arginine (100 µM), the natural precursor of NO synthesis, enhanced NMDA‐evoked release of [3H]NA (100%) and d‐[3H]Asp (700%).”

“Substrates for system A [alpha-(methylamino)isobutyric acid] and an anionic carrier L-aspartate ) were poor cis-inhibitors of L-arginine entry.”