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“ L-arginine in combination with artesunate (32 mg/kg) induced immediate reversal of brain ischemia in the short-term (1 hour), but the effect subsided after 3 and 6 hours.”
“Slow, continuous delivery of L-arginine by osmotic pumps, or combined bolus administration of artesunate with L-arginine , also prevented worsening of pial constriction and resulted in improved survival of mice with ECM.”