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“ABSTRACT Background Pegylated arginine deiminase ADI-PEG 20) is a metabolism-based strategy that depletes arginine , resulting in tumoral stress and cytotoxicity.”
“We demonstrated that prolonged arginine starvation by exposure to ADI-PEG20 (pegylated arginine deiminase) induced autophagy-dependent death of ASS1-deficient breast cancer cells, because these cells are arginine auxotrophs (dependent on uptake of extracellular arginine).”
“Starving ASS1-deficient cells of arginine with arginine blockers such as ADI-PEG20 can induce selective lethality and has shown great promise in the clinical setting.”