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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Arginine
drug:
Adi-Peg 20
Research Papers that Mention the Interaction
“ABSTRACT Background Pegylated arginine deiminase ADI-PEG 20) is a metabolism-based strategy that depletes arginine , resulting in tumoral stress and cytotoxicity.”
“In summary, ADI-PEG20 inhibits HIF-activated processes in two tumour models with widely different arginine biology.”
“We demonstrated that prolonged arginine starvation by exposure to ADI-PEG20 (pegylated arginine deiminase) induced autophagy-dependent death of ASS1-deficient breast cancer cells, because these cells are arginine auxotrophs (dependent on uptake of extracellular arginine).”
Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells“Starving ASS1-deficient cells of arginine with arginine blockers such as ADI-PEG20 can induce selective lethality and has shown great promise in the clinical setting.”
“Pegylated arginine deiminase ADI-PEG20 ) results in the depletion of arginine with the production of isomolar amounts of citrulline.”
Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs.“However, ADI-PEG 20-induced arginine deprivation is known to increase serine biosynthesis, glutamine anaplerosis, oxidative Editorial”
Optimizing arginine deprivation for hard-to-treat cancers
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