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Last Updated: 4 years ago

Possible Interaction: Arginine and Adi-Peg 20

supplement:

Arginine

Research Papers that Mention the Interaction

ABSTRACT Background Pegylated arginine deiminase ADI-PEG 20) is a metabolism-based strategy that depletes arginine , resulting in tumoral stress and cytotoxicity.
Oncoimmunology  •  2021  |  View Paper
In summary, ADI-PEG20 inhibits HIF-activated processes in two tumour models with widely different arginine biology.
Scientific reports  •  2016  |  View Paper
We demonstrated that prolonged arginine starvation by exposure to ADI-PEG20 (pegylated arginine deiminase) induced autophagy-dependent death of ASS1-deficient breast cancer cells, because these cells are arginine auxotrophs (dependent on uptake of extracellular arginine).
Science Signaling  •  2014  |  View Paper
Starving ASS1-deficient cells of arginine with arginine blockers such as ADI-PEG20 can induce selective lethality and has shown great promise in the clinical setting.
Cell reports  •  2016  |  View Paper
Pegylated arginine deiminase ADI-PEG20 ) results in the depletion of arginine with the production of isomolar amounts of citrulline.
American journal of physiology. Endocrinology and metabolism  •  2021  |  View Paper
However, ADI-PEG 20-induced arginine deprivation is known to increase serine biosynthesis, glutamine anaplerosis, oxidative Editorial
Oncotarget  •  2017  |  View Paper