Possible Interaction: Arginine and 3-Nitrotyrosine

“ L-arginine did not enhance TNF-induced increases of superoxide and peroxynitrite production but further increased TNF-induced increase of nitrotyrosine production and exacerbated TNF-mediated cell apoptosis.”

“Further, L-arginine increased ENO levels and cyclic guanosine monophosphate in lung and reduced the markers of nitro-oxidative stress such as nitrotyrosine , 8-isoprostane, and 8-hydroxy-2'-deoxyguanosine.”

“Our results indicate that l-arginine actually prevents TBI-induced increases in NT immunoreactivity.”

“Second, we tested the hypothesis that treatment with l-arginine , a substrate for nitric oxide synthase, further increases NT immunoreactivity over TBI alone.”

“HCY induced formation of the peroxynitrite biomarker nitrotyrosine , which was blocked by supplemental L-arginine.”

“In strict contrast, administration of L-arginine 3 h after reperfusion, a time point when iNOS was expressed, resulted in a significant increase in myocardial NO(x) content, myocardial injury, and toxic peroxynitrite formation as measured by nitrotyrosine.”

“The introduction of one mononitrotyrosine per mole of arginine kinase results in a total loss of activity.”

“ l-arginine augmented and prolonged cold-induced UCP1 and nitrotyrosine immunopositivity, NF-κB activation and SODs mRNA expression increase, while l-NAME expressed an opposite effect.”