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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
supplement:
Vitamin K
Research Papers that Mention the Interaction
“This study shows that menatetrenone inhibited PGE2 release from cells by inhibiting both PG production steps, AA release from the membrane and PG synthesizing activity with AA.”
Vitamin K2 (menatetrenone) inhibits prostaglandin synthesis in cultured human osteoblast-like periosteal cells by inhibiting prostaglandin H synthase activity.“Here we report that vitamin K at nanomolar concentrations prevents arachidonic acid‐induced oxidative injury to pre‐OLs through blocking the activation of 12‐lipoxygenase (12‐LOX).”
“ Vitamin K1 and MK‐4 significantly blocked 12‐LOX activation and prevented ROS accumulation in pre‐OLs challenged with arachidonic acid.”
Vitamin K prevents oxidative cell death by inhibiting activation of 12‐lipoxygenase in developing oligodendrocytes“ CMN was the most potent in inhibiting the aggregation and release reaction induced by ADP, arachidonic acid , PAF, ionophore A23187, collagen and thrombin in a dose-dependent manner in washed platelets, platelet-rich-plasma and whole blood.”
“Therefore, vitamin K1 modulates the release of AA in vascular cells and thus inhibits the capacity of blood vessels to synthesize PGI2.”
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