Possible Interaction: Arachidonic Acid and Vitamin E

“Similarly, to explain the greater increase in citraturia in W compared to B, we speculate that inhibition of lipogenesis of arachidonic acid by vitamin E , ultimately leading to an increase in citraturia, occurs to a lesser extent in B than in W.”

“Platelet function was significantly decreased by vitamin E as revealed by the decreased platelet aggregation in response to ADP and arachidonic acid , the increased sensitivity to inhibition by PGE1, the decreased plasma beta-thromboglobulin concentration and the decreased ATP secretion.”

“It has been reported that normal plasma levels of tocopherol may enhance the lipoxygenation of arachidonic acid , whereas higher tocopherol levels exert a suppressive effect that is consistent with its role as a hydroperoxide scavenger.”

“ Vitamin E and GSH-Px may modulate arachidonic acid metabolism and the activity of cyclooxygenase enzymes by affecting peroxide concentration.”

“Although all antioxidants were found to be effective in decreasing oxidant-stimulated peroxide formation, only alpha-tocopherol significantly decreased oxidant-stimulated release of 3H-labeled arachidonic acid (AA), while ascorbic acid markedly increased release.”

“The increase in PPARgamma and the reduction in ALDH3A1 were also prevented by exposing cells to vitamin E concomitant with arachidonic acid treatment.”

“We have previously reported that vitamin E enrichment potentiates the arachidonic acid release as well as the spontaneous prostacyclin release in human endothelial cells.”

“Regardless of the administration route, vitamin E reduced mitochondrial uncoupling, cytochrome c release and apoptosis of mononuclear cells, as did the 5-lipoxygenase inhibitor eicosatetraynoic acid.”

“The possible role of the interaction effect between arachidonic acid and vitamin E in breast cancer risk requires further investigation.”

“Kappus and Diplock15 stated that vitamin E affects the metabolism of arachidonic acid.”

“ Vitamin E may have a biphasic effect on the arachidonic acid cascade in which moderate amounts stimulate the biosynthesis of prostaglandin and large amounts may inhibit it.”