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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
drug:
Vincristine
Research Papers that Mention the Interaction
“Abstract We have demonstrated … in vitro addition of vincristine to human platelets: 1) inhibits aggregation induced by arachidonic acid , epinephrine, collagen, thrombin and ADP; 2) inhibits arachidonic acid conversion to thromboxane A 2 ; and 3) inhibits generation of thromboxane A 2 upon stimulation by mechanical agitation, collagen, or thrombin.”
In vitro effects of vincristine on arachidonic acid metabolism in human platelets and rat arterial tissue.“Maximal aggregation after administration of VCR was significantly lower in response to ADP, COL, and AA (P = .03, P = .04, and P = .03, respectively).”
Vincristine impairs platelet aggregation in dogs with lymphoma.
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