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“These include inadequate production or reduction of bioavailability of nitric oxide, alterations in metabolism of arachidonic acid , resulting in an increase in vasoconstrictors and decrease in vasodilators , and upregulation of endothelin.”
American journal of physiology. Regulatory, integrative and comparative physiology • 2003 | View Paper
“…,renal vasodilation … AA was greater in the SHR at high PP; for example, 2.5, 5, and 10 &mgr;g of AA produced PP declines of … mm Hg, respectively, in SHR compared with 26±3, 45±5, and 77±6 mm Hg in Wistar-Kyoto rats (P <0.01).”